Nathan S. Kline Institute
  • 10-Oct-2017 to 15-Nov-2017 (EST)
  • Nathan Kline Institute
  • Orangeburg, NY, USA
  • $47,484.00
  • Salary
  • Full Time

Full Benefits Package


JOB DESCRIPTION:

Two newly NIA-funded postdoctoral positions for recent Ph.D. are available immediately in the laboratory of Dr. Levy at the NKI.

  1. The first position focuses on the anti-amyloidogenic and neuroprotective properties of a novel, naturally occurring mutation in the amyloid beta peptide found in an Italian family. This post-doctoral fellow will investigate whether the interaction between the Italian amyloid beta, which contains an amino acid substitution at residue 2 of amyloid beta, and wild-type amyloid beta hinders amyloid beta oligomerization, amyloidogenesis and neurotoxicity using unique transgenic mouse models. Overall, these studies will address multiple mechanisms by which Italian amyloid beta appears to be protective. Additionally, this applicant will use exosomes as vehicles to deliver protective Italian amyloid beta within the brain, a novel therapeutic approach for Alzheimer's disease.
  2. A second research position is part of a collaborative undertaking including Drs. Paul M. Mathews and Donald A. Wilson, also at the NKI and NYU School of Medicine, investigating cell biological responses to different apolipoprotein E alleles that either protect from or predispose neurons to neurodegenerative risk both early in AD as well as independently of hallmark AD pathology. Our studies examine vesicular trafficking and functional differences in the endosomal and exosomal systems mediated by apolipoprotein E. Experimental models include human brain tissue, mouse models, and in vitro culture systems. Therapeutic strategies building upon the protective effects of apolipoprotein E2 are one of the long-term goals of this project.

 

These studies routinely employ multidisciplinary approaches including behavioral tests of mouse models, and electron microscopy, immunolabeling, standard biochemistry, as well as genomic, proteomic and lipidomic approaches of mouse brain tissue, human postmortem brain tissue, and in vitro cultured cells.

JOB DUTIES:

  • These individuals will work closely with the P.I. performing experiments, analyzing data, and writing manuscripts
  • rodent husbandry, including familiarity with standard behavioral assessments
  • cell culture, primary neuronal cultures
  • tissue and cell immunolabeling for confocal microscopy
  • PCR, Western blot, subcellular fractionation

JOB QUALIFICATIONS:

  • Applicants must have a recent Ph.D. or the equivalent
  • A strong research and record of written productivity as evidenced by peer-reviewed publications in international journals and potentially fellowship applications.

 

  • The candidate must have the ability to work efficiently, great problem-solving ability, excellent organizational skills, be fluent in English, should have good writing skills, and excellent interpersonal skills.

*The Research Foundation is a private not-for-profit corporation and is not an agency or instrumentality of the State of New York.  Employees of the Research Foundation are not state employees, do not participate in any state retirement system, and do not receive state fringe benefits. Excellent Benefits Package. Affirmative Action/Equal Opportunity Employer/Minority/Women/Disabled/Veteran Employer. VEVRAA 41 CFR 60-300.5(a) compliant.

 

Applications will only be accepted through website at: http://corporate.rfmh.org - Click on Employment Opportunities. Applications will be accepted only during the posting dates as listed at the top of the job announcement.

Questions regarding this position please email: hr@rfmh.org

 

Nathan S. Kline Institute
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